Furosemide (Lasix) Tablets
Furosemide is a loop diuretic. The active ingredient is dispensed as oral tablets (20 mg, 40 mg and 80 mg) and an oral solution.
Furosemide is used to treat fluid retention that often occurs in patients with liver or kidney disease, and congestive heart failure. The excess fluid is eliminated from the body by urination. Furosemide also prevents the body from absorbing excessive amounts of salt.
Furosemide is used to treat other medical conditions not listed in this information guide.
Adults will typically begin with a single dose of 20 mg to 80 mg for fluid retention problems. In patients eith high blood pressure often begin with 40 mg, twice per day.
Furosemide must always be used as directed. Do not make adjustments to the dose before speaking to a doctor.
If using the oral solution ensure that each dose is measured using a proper medical measuring device to ensure that the correct dosage is dispensed.
Furosemide is sometimes taken when required so this will not apply. If, however, your are on a scheduled dosage and you miss a dose, it may be taken when you remember. However, do not take the missed dose near the time of the next scheduled dose. In this case, ignore the missed dose. Never double-up on a dose.
Furosemide Warnings and Precautions
Do not use Furosemide if you are allergic to furosemide.
Tell your doctor if you suffer with any of the following: gout, diabetes, lupus, liver or kidney disease, or if you are allergic to sulfa drugs.
While using Furosemide you will need to have regular blood tests to ensure that the medication is having the desired effect. Your doctor may also wish to regularly check that your liver and kidneys are functioning correctly.
Furosemide is likely to cause increased urination, so ensure that you do not get dehydrated. Drink plenty of fluids. Ask your doctor about eating foods with a high content of potassium, or taking potassium supplements.
If you are using Furosemide to treat high blood pressure, do not stop taking this medication even if you are feeling fine. There are often no obvious symptoms of high blood pressure.
It is not known if Furosemide is harmful to an unborn fetus, so pregnant women should use this drug with caution. Women who are breast-feeding should also use Furosemide with caution as this drug passes into breast milk.
Before using Furosemide, you must give your doctor full details of your medical history and other medications that you use. These include herbal medicines and vitamin supplements. Furosemide can react badly with some medications.
Possible Side Effects of Furosemide
Get emergency help if any of the following symptoms of allergy occur: hives, difficulty in breathing, or swelling of the face, tongue, lips or throat.
Contact your doctor immediately if any of the following side-effects occur: nausea or vomiting, weakness, drowsiness, thirst, restlessness, lightheadedness, fast or irregular heartbeat, decreased urination, muscle pain, easy bleeding or bruising, skin rash (with peeling or blistering), stomach pain, lack of appetite, low fever, clay-colored stools, dark urine, or jaundice.
Less serious side-effects may include stomach pain, headache, diarrhea or constipation, numbness, dizziness, vision problems, or burning or tingling sensation.
Contact your doctor if any uncomfortable symptoms occur, or persist. Other side effects of diuretics.
Call for emergency help immediately. Symptoms of overdose can include lack of appetite, weakness, dizziness, ringing in the ears, confusion, or fainting.
Furosemide must be kept away from children and stored in a dry, cool place away from sunlight and moisture.
Side Effects of Diuretics
The human lifestyle has become more mechanic today. Gone are the days where a person would want to rest for hours and to rejuvenate himself. Hectic schedule, busy work routine, unhealthy eating habits, the longing habits of smoking as well as alcohol contribute together in making the overall health of a person even worse. Thus, following this lifestyle, an individual often falls prey to a number of big and small illnesses.
The illnesses such as heart disease, kidney disease, common cold, allergies, high blood pressure, low blood pressure, etc. have become very common among the people today. The irony is that these illnesses do not target people of a particular age, but can possess equal dangers to the young as well as old ones. Out of all these problems, the problem of blood pressure has become very common today. In fact, two out of every five people are suffering from the problem of blood pressure in the recent times.
Blood pressure has a number of reasons behind it. Likewise, a blood pressure could be treated in a number of ways. One such common drug which is associated with the treatment of blood pressure in people is diuretics. This drug is more commonly known as water pills and is considered to be an effective treatment for the problem of blood pressure.
Water pills are nothing but the drugs that aid the kidney of a person to shed off the presence of extra water as well as salt from the body. This is done by the way of pee. Since the total fluid into your blood vessels is less, the pressure inside remains lower. This process also makes the pumping of the heart very easy and keeps you fit. Diuretics have become one of the most common treatments for blood pressure and a majority of doctor put this drug on the first place whenever the regard of treatment of blood pressure is taken under consideration.
Diuretics: Treat your blood pressure, strive towards a healthy being!
The most common form of the condition that diuretics treats very easily is high blood pressure. This is done by the way of reducing the amount of extra fluid of a person’s blood vessels. Apart from blood pressure, diuretics also helps to control other conditions and disturbances in the internal system of the human namely, congestive heart failure, the problem of edema, fluid buildup and many others.
Side-effects caused by Diuretics:
Although diuretics is referred to as one of the safest treatments for the control of blood pressure in people, yet there are chances that a person could suffer from various side-effects during his course of medication. Some of these side-effects are very common in nature, while others are rare.
Common side effects:
The common side-effects caused because of the medication of water pills or diuretics are thirst, weakness, dry mouth, restlessness, drowsiness, lethargy, seizures, confusion, muscle pains and cramps, decrease or absence as to the production of urine and many others.
Serious side effects:
The more serious side effects that a person faces while on the treatment of diuretics are kidney failure, allergic reaction, and irregular heartbeat.
In both the cases of side-effects caused as a result of intake of diuretics, you must consult your doctor or physician at once and get yourself tested.
Neuromuscular Blockers and Furosemide
The effects of the neuromuscular blockers may be increased by low doses of frusemide but opposed by higher doses.
Three patients receiving kidney transplants showed increased neuromuscular blockade with tubocuranne (seen as a pronounced decrease in twitch tension) when given frusemide (40 or 80 mg) and mannitol (12,5 mg) intravenously. One of them showed the same reaction when later given only 40 mg frusemide but no mannitol. The residual blockade was easily antagonized with pyndostigmine (14 mg) or neostigmine (3 mg) with atropme (12 mg).
10 patients given 1 mg/kg frusemide took 14 7 mm to recover from 95 to 50% blockade with pancuroraum (as measured by a twitch response) compared with 21,8 mm in 10 other patients who had had no frusemide.
Uncertain Animal studies indicate that what happens probably depends on the dosage of frusemide 0 1-10 (ig/kg increased the blocking effects of tubocuranne and suxamethomum whereas 1-4 mg/kg opposed the blockade. One suggestion is that low doses of frusemide inhibit protein kmase, whereas higher doses cause inhibition of phosphodiesterase.
Importance and management
The documentation is very limited. Be on the alert for changes in the response to any blocker if frusemide is used Animal studies suggest that increases occur with doses less than 10 ugl kg, but decreases with doses of 1-4 mg/ kg. Whether these same changes occur if frusemide is given orally seems not to have been studied.
What are Loop Diuretics
Diuretics are popular medications also known as "water tablets" or "water pills". Their target operation is to release an excess amount of fluids from the body of the patient through the kidneys in the form of urine. They are quite well-known in the world of pharmacy. They are not only of a single type. They are found in three different kinds and are popular for different uses.
Loop diuretics are of them. Some of the popular examples of this class of diuretics are torasemide, bumetanide, and furosemide. They are available in different trade or brand names in the market. Loop diuretics are used for treating conditions like heart failure. When the heart does not pump blood adequately to all the parts of the body, it results in fluid accumulation. Sometimes, fluid may accumulate in the lungs causing breathing difficulties. The legs and ankles may swell up due to the storage of excess fluid in the body tissues. Here, loop diuretics help majorly for releasing the extra fluid.
This medication is also useful in treating other medical conditions as well that lead to fluid build-up like kidney or liver disorders. At times, hypertension caused by high blood pressure is also treated using this medication. But, for hypertension, the type called thiazide diuretics is preferred more often.
How Do They Work?
The mechanism loop diuretics use is to allow greater fluid passage from the kidneys. The water and salt transportation to particular cells in the kidneys are manipulated to carry out this function. These cells are located in a particular structure known as the loop of Henle. Loop diuretics got its name from this structure. The kidneys have so many of these loops. As fluid is released from the kidneys, a lesser amount of fluids remains in the bloodstream. This makes the excess fluid in any part of the body to be drawn out in the bloodstream as a replacement. This will eventually help in easing symptoms like breathlessness and oedema.
Side effects of Loop Diuretics
Diuretics are prescribed to patients in very low doses. Hence, the chances of the occurrence of side effects are very unusual. But, if the dose is high, there might be some unnecessary changes in the body. The leaflets of this medicine has all the information about the side effects. Patients who are prescribed this medication must read them carefully. Some of the common side effects are:
- Metabolic alkalosis
- Dehydration ( also called hypovolemia), causing hypotension
- Hearing loss also called ototoxitcity (dose-related)
- Stomach upset
- In case the patient has gout or diabetes, the condition can worsen
The doctor must be informed immediately if the side effects go out of control for immediate assistance.
Things to Consider
Loop diuretics are prescribed to be taken once daily each morning. The effect usually takes about half an hour to begin. The patient will develop the urge to use the washroom more often than usual. But, it wears off in about 6 hours.